Simple and Rapid Colorimetric Biosensors Based on DNA Aptamer and Noncrosslinking Gold Nanoparticle Aggregation

ChemBioChemVolume 8, Issue 7 p. 727-731 Communication Simple and Rapid Colorimetric Biosensors Based on DNA Aptamer and Noncrosslinking Gold Nanoparticle Aggregation Weian Zhao, Weian Zhao Department of Chemistry, McMaster University, 1280 Main St., W. Hamilton, ON, L8S 4M1, Canada, Fax: (+1) 905-522-9033Search for more papers by this authorWilliam Chiuman, William Chiuman Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St., W. Hamiltion, ON, L8N 3Z5, CanadaSearch for more papers by this authorMichael A. Brook Prof. Dr., Michael A. Brook Prof. Dr. [email protected] Department of Chemistry, McMaster University, 1280 Main St., W. Hamilton, ON, L8S 4M1, Canada, Fax: (+1) 905-522-9033Search for more papers by this authorYingfu Li Prof. Dr., Yingfu Li Prof. Dr. [email protected] Department of Chemistry, McMaster University, 1280 Main St., W. Hamilton, ON, L8S 4M1, Canada, Fax: (+1) 905-522-9033 Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St., W. Hamiltion, ON, L8N 3Z5, CanadaSearch for more papers by this author Weian Zhao, Weian Zhao Department of Chemistry, McMaster University, 1280 Main St., W. Hamilton, ON, L8S 4M1, Canada, Fax: (+1) 905-522-9033Search for more papers by this authorWilliam Chiuman, William Chiuman Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St., W. Hamiltion, ON, L8N 3Z5, CanadaSearch for more papers by this authorMichael A. Brook Prof. Dr., Michael A. Brook Prof. Dr. [email protected] Department of Chemistry, McMaster University, 1280 Main St., W. Hamilton, ON, L8S 4M1, Canada, Fax: (+1) 905-522-9033Search for more papers by this authorYingfu Li Prof. Dr., Yingfu Li Prof. Dr. [email protected] Department of Chemistry, McMaster University, 1280 Main St., W. Hamilton, ON, L8S 4M1, Canada, Fax: (+1) 905-522-9033 Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main St., W. Hamiltion, ON, L8N 3Z5, CanadaSearch for more papers by this author First published: 24 April 2007 https://doi.org/10.1002/cbic.200700014Citations: 193Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract The color purple. Upon binding of the target +, negatively charged DNA aptamers (shown in purple) dissociate from a gold nanoparticle surface; this results in nanoparticle aggregation and a color change at a chosen salt concentration. References 1 1aR. Elghanian, J. J. Storhoff, R. C. Mucic, R. L. Letsinger, C. A. Mirkin, Science 1997, 277, 1078; 1bL. M. Demers, C. A. Mirkin, R. C. Mucic, R. A. Reynolds, R. L. Letsinger, R. Elghanian, G. Viswanadham, Anal. Chem. 2000, 72, 5535. 2 2aJ. Liu, Y. Lu, J. Am. Chem. Soc. 2003, 125, 6642; 2bJ. Liu, Y. Lu, J. Am. Chem. Soc. 2004, 126, 12298. 3 3aY. Chen, S. Chen, Y. Chien, Y. Chang, H. Liao, C. Chang, M. Jan, K. Wang, C. Liu, ChemBioChem 2005, 6, 1169; 3bC. Huang, Y. Huang, Z. Cao, W. Tan, H. Chang, Anal. Chem. 2005, 77, 5735. 4G. Mie, Ann. Phys. 1908, 25, 377. 5 5aJ. Liu, Y. Lu, Angew. Chem. 2006, 118, 8123; Angew. Chem. Int. Ed. 2006, 45, 90; 5bJ. Liu, Y. Lu, Nat. Protoc. 2006, 1, 246; 5cJ. Liu, Y. Lu, Adv. Mater. 2006, 18, 1667. 6 6aA. D. Ellington, J. W. 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