Effects of Inhibition of the Polyol Pathway during Chronic Peritoneal Exposure to a Dialysis Solution

腹膜透析 医学 多元醇 透析 多元醇途径 重症监护医学 药理学 内科学 泌尿科 内分泌学 化学 有机化学 醛糖还原酶 聚氨酯 糖尿病
作者
Roos van Westrhenen,Jan Aten,Medhanit Aberra,Cindy A M Dragt,Gregory Deira,Raymond T. Krediet
出处
期刊:Peritoneal Dialysis International [SAGE Publishing]
卷期号:25 (3_suppl): 18-21 被引量:11
标识
DOI:10.1177/089686080502503s05
摘要

♦ Background Peritoneal dialysis with glucose- and lactate-containing dialysis solutions stimulates peritoneal angiogenesis and fibrosis. These serious side effects can also be induced by chronic peritoneal exposure to dialysis solutions in nonuremic rats. The high glucose concentrations of the dialysis solutions may saturate physiological glucose metabolism pathways and stimulate the polyol pathway that has been described to damage nerves and vessels in diabetes mellitus. To investigate the role of the polyol pathway in the development of fibrosis and angiogenesis during chronic peritoneal exposure, the rate-limiting aldose reductase activity in the polyol pathway was inhibited in a chronic peritoneal exposure model in the rat, in which different administration routes were compared. ♦ Experimental Procedures Three groups of rats received daily intraperitoneal infusion with lactate/glucose (3.86%)- containing dialysate via a peritoneal catheter with a subcutaneous puncture device, for 14 weeks: group 1 received only the dialysis solution, groups 2 and 3 received, in addition, zopolrestat, administered either orally (group 2) or intraperitoneally (group 3). After sacrifice, omental tissue was examined by histology for the presence of fibrosis (Picro Sirius Red) and the number of blood vessels (CD31). ♦ Results Histology revealed significantly less Picro Sirius Red-positive tissue in perivascular areas of both experimental groups and submesothelial areas of the oral group in comparison to the control group. There were significantly fewer CD31-positive vessels per field in both groups treated with zopolrestat compared to the infusion-only group: group 2, 9 (7 – 12); group 3, 17 (13 – 38), compared to group 1, 37 (32 – 39), p < 0.05. ♦ Conclusion The combination of peritoneal exposure to dialysis fluids and administration of zopolrestat, a newly developed inhibitor of aldose reductase activity, resulted in less fibrosis and fewer peritoneal vessels than exposure to dialysis fluids only, in a long-term exposure model in the rat. Inhibition of the polyol pathway may thus offer an important contribution to allow long-term continuation of peritoneal dialysis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Yunsong完成签到,获得积分10
1秒前
耶路生完成签到,获得积分10
2秒前
hyl发布了新的文献求助10
2秒前
3秒前
小猴子完成签到,获得积分20
4秒前
lilililininini完成签到,获得积分20
4秒前
6秒前
7秒前
Ceka完成签到,获得积分10
8秒前
9秒前
9秒前
hyl完成签到,获得积分10
10秒前
积极的初南完成签到,获得积分10
11秒前
Livrik发布了新的文献求助10
12秒前
小小完成签到 ,获得积分10
12秒前
笨笨山芙发布了新的文献求助10
13秒前
14秒前
14秒前
15秒前
15秒前
16秒前
17秒前
量子星尘发布了新的文献求助10
18秒前
Livrik完成签到,获得积分10
18秒前
小猴子关注了科研通微信公众号
18秒前
阿Q完成签到,获得积分10
19秒前
yujd完成签到,获得积分10
19秒前
鹿仪发布了新的文献求助10
19秒前
19秒前
19秒前
Orange应助好宝宝采纳,获得10
21秒前
21秒前
GL发布了新的文献求助10
22秒前
22秒前
李健应助年轻的烨华采纳,获得10
24秒前
Jasper应助zhugepengju采纳,获得10
24秒前
25秒前
酢浆草小熊完成签到 ,获得积分10
25秒前
沈昊泽完成签到,获得积分10
28秒前
陈浩发布了新的文献求助10
28秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988868
求助须知:如何正确求助?哪些是违规求助? 3531255
关于积分的说明 11253071
捐赠科研通 3269858
什么是DOI,文献DOI怎么找? 1804822
邀请新用户注册赠送积分活动 881994
科研通“疑难数据库(出版商)”最低求助积分说明 809035