Wnt信号通路
丹麦克朗
生物
生物信息学
基因
转录因子
信号转导
连环蛋白
遗传学
癌变
细胞生物学
计算生物学
LRP6型
调节器
作者
Atsushi Niida,Takatoshi Hiroko,Mana Kasai,Yoichi Furukawa,Yusuke Nakamura,Yutaka Suzuki,Sumio Sugano,Tetsu Akiyama
出处
期刊:Oncogene
[Springer Nature]
日期:2004-09-20
卷期号:23 (52): 8520-8526
被引量:502
标识
DOI:10.1038/sj.onc.1207892
摘要
Wnt signaling plays an important role in embryonic development and tumorigenesis. These biological effects are exerted by activation of the β-catenin/TCF transcription complex and consequent regulation of a set of downstream genes. TCF-binding elements have been found in the promoter regions of many TCF target genes and characterized by a highly conserved consensus sequence. Utilizing this consensus sequence, we performed an in silico screening for new TCF target genes. Through computational screening and subsequent experimental analysis, we identified a novel TCF target gene, DKK1, which has been shown to be a potent inhibitor of Wnt signaling. Our finding suggests the existence of a novel feedback loop in Wnt signaling.
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