神经病理学
老年斑
病理
脑淀粉样血管病
阿尔茨海默病
血管病
淀粉样蛋白(真菌学)
医学
痴呆
内分泌学
疾病
糖尿病
作者
Sang Won Suh,Knud B. Jensen,Morten Skovgaard Jensen,David S. Silva,Patrick Kesslak,Gorm Danscher,Christopher J. Frederickson
出处
期刊:Brain Research
[Elsevier]
日期:2000-01-01
卷期号:852 (2): 274-278
被引量:324
标识
DOI:10.1016/s0006-8993(99)02096-x
摘要
Excess brain zinc has been implicated in Alzheimer's neuropathology. Here we evaluated that hypothesis by searching the brains of Alzheimer's patients for abnormal zinc deposits. Using histochemical methods, we found vivid Zn2+ staining in the amyloid deposits of dense-core (senile) plaques, in the amyloid angiopathy surrounding diseased blood vessels, and in the somata and dendrites of neurons showing the characteristic neurofibrillary tangles (NFT) of Alzheimer's. In contrast, brains from age-matched, non-demented subjects showed only occasional staining for Zn2+ in scattered neurons and possible plaques. A role of abnormal zinc metabolism in Alzheimer's neuropathology is suggested.
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