西塔
川东北74
生物
抗原处理
MHC I级
主要组织相容性复合体
MHC II级
MHC限制
抗原呈递
交易激励
与抗原处理相关的转运体
遗传学
免疫系统
基因
T细胞
基因表达
作者
Torsten Meißner,Amy Li,Koichi S. Kobayashi
标识
DOI:10.1016/j.micinf.2011.12.007
摘要
Major histocompatibility complex (MHC) class I and class II are crucial for the function of the human adaptive immune system. An NLR protein, CIITA (MHC class II transactivator), is a master regulator of MHC class II gene expression as well as of some of the genes involved in MHC class II antigen presentation. It has recently been discovered that another member of the NLR protein family, NLRC5, transcriptionally activates MHC class I genes, and thus acts as "CITA" (MHC class I transactivator), a counterpart to CIITA. In addition to MHC class I genes, NLRC5 can induce the expression of β2M, TAP1 and LMP2, essential components of MHC class I antigen presentation. These findings indicate that NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and MHC class II pathways, respectively.
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