逆转录酶
底漆(化妆品)
聚合酶
DNA聚合酶
化学
核苷酸
DNA
分子生物学
生物
计算生物学
生物化学
聚合酶链反应
基因
有机化学
作者
Sylvie Doublié,M.R. Sawaya,Tom Ellenberger
出处
期刊:Structure
[Elsevier]
日期:1999-02-01
卷期号:7 (2): R31-R35
被引量:307
标识
DOI:10.1016/s0969-2126(99)80017-3
摘要
The recently determined structures of HIV-1 reverse transcriptase and Taq DNA polymerase in complex with DNA primer–template and an incoming nucleotide have shown that a large conformational change configures the polymerase active site for nucleotidyl transfer. The structure of reverse transcriptase in the catalytic complex will open the path to the rational design of novel nucleoside analog inhibitors of viral replication.
科研通智能强力驱动
Strongly Powered by AbleSci AI