唾液腺
放射治疗
头颈部癌
辐射敏感性
医学
头颈部
辐射灵敏度
涎腺癌
癌症
病理
内科学
辐照
外科
物理
核物理学
作者
Oliver Grundmann,Geoffrey C. Mitchell,Kirsten H. Limesand
标识
DOI:10.1177/0022034509343143
摘要
Radiation therapy for head and neck cancer causes significant secondary side-effects in normal salivary glands, resulting in diminished quality of life for these individuals. Salivary glands are exquisitely sensitive to radiation and display acute and chronic responses to radiotherapy. This review will discuss clinical implications of radiosensitivity in normal salivary glands, compare animal models used to investigate radiation-induced salivary gland damage, address therapeutic advances, and project future directions in the field.
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