二十碳五烯酸
DMBA公司
六烯酸
内科学
内分泌学
花生四烯酸
医学
药理学
乳腺
化学
癌变
脂肪酸
多不饱和脂肪酸
乳腺癌
癌症
生物化学
酶
作者
Masakuni Noguchi,Masaki Minami,Ryo Yagasaki,Kazuo Kinoshita,Mitsuharu Earashi,Hirohisa Kitagawa,Takao Taniya,Itsuo Miyazaki
摘要
We investigated the effects of low-dose eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the incidence and growth of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats fed a high-fat (HF) diet. We also examined the effects of these treatments on the fatty acid composition of tumour and serum. Tumour incidence was significantly decreased by the administration of low-dose EPA and DHA, whereas their inhibitory effects on tumour growth did not reach significance. Serum arachidonic acid (AA) level was decreased by the administration of low-dose EPA and tended to be decreased by the administration of low-dose DHA, whereas tumour AA levels were not changed. The administration of low-dose EPA and DHA may be useful for inhibiting the incidence of breast cancer.
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