黏膜黏附
泊洛沙姆
流变仪
化学
口腔给药
化学工程
药物输送
色谱法
剂型
流变学
材料科学
肺表面活性物质
粘弹性
泊洛沙姆407
生物医学工程
粘度
复合材料
聚合物
动态力学分析
剪切减薄
毒品携带者
水溶液
药理学
共聚物
有机化学
医学
生物化学
作者
Esra Baloğlu,Sinem Yaprak Karavana,Zeynep Ay Şenyiğit,Tamer Güneri
标识
DOI:10.3109/10837450.2010.508074
摘要
This study described the thermosensitive formulations composed of poloxamer mixtures for use as drug delivery platform via mucosal route. It also characterized the poloxamer mixtures' rheological, mechanical and mucoadhesive properties. Poloxamer (Plx) 407 and Plx 188 were used alone and together for preparing the mucosal drug delivery platform. The mixtures of Plx 407 and Plx 188 in ratio of 15:15 (F5); 15:20 (F6); 20:10 (F7) existed liquid at room temperature, but gelled at physiological temperature. Flow rheometry studies and oscillatory analysis of each formulation were performed at 20 ± 0.1°C and 37 ± 0.1°C. F5 and F7 formulations exhibited typical gel-type mechanical spectra (G' > G″) after the determined frequency value at 37°C whereas F6 behaved as weakly cross-linked gel. Texture profile analysis presented that F5 and F7 showed similar mechanical properties and can be used as base for mucosal dosage form. Mucoadhesion studies indicated the difference among the formulations and the effect of the mucosal surface on mucoadhesive properties. Mucin disc, bovine vaginal and buccal mucosa were used as mucosal platform for mucoadhesion studies. It is suggested that these investigations may be usefully combined to provide a more rational basis for selecting the ratio of Plx to prepare a topical thermosensitive drug delivery system for mucosal administration.
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