Gatifloxacin-Induced Hepatotoxicity and Acute Pancreatitis

Letters6 January 2004Gatifloxacin-Induced Hepatotoxicity and Acute PancreatitisOnki Cheung, MD, Kapil Chopra, MD, Tina Yu, MD, Michael A. Nalesnik, MD, Shirish Amin, MD, and A. Obaid Shakil, MDOnki Cheung, MDFrom University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and Indiana Hospital, Indiana, PA 15701.Search for more papers by this author, Kapil Chopra, MDFrom University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and Indiana Hospital, Indiana, PA 15701.Search for more papers by this author, Tina Yu, MDFrom University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and Indiana Hospital, Indiana, PA 15701.Search for more papers by this author, Michael A. Nalesnik, MDFrom University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and Indiana Hospital, Indiana, PA 15701.Search for more papers by this author, Shirish Amin, MDFrom University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and Indiana Hospital, Indiana, PA 15701.Search for more papers by this author, and A. Obaid Shakil, MDFrom University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and Indiana Hospital, Indiana, PA 15701.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-140-1-200401060-00036 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Background: Quinolones may induce transient abnormalities in serum aminotransferase levels. Severe hepatotoxicity and acute pancreatitis are rare. Gatifloxacin (Tequin, Bristol-Myers Squibb, New York, New York) is one of the newest members of the group (1). Increased serum bilirubin, aminotransferase, or amylase levels occur in less than 1% of patients exposed; 1 case of acute hepatitis has been reported (2).Objective: We describe 2 patients who developed acute cholestatic liver injury and acute pancreatitis while being treated with gatifloxacin.Case Reports: Patient 1, a 41-year-old woman, was treated for an upper respiratory tract infection with oral ciprofloxacin. After ...References1. Fish DN, North DS. Gatifloxacin, an advanced 8-methoxy fluoroquinolone. Pharmacotherapy. 2001;21:35-59. [PMID: 11191737] CrossrefMedlineGoogle Scholar2. Henann NE, Zambie MF. Gatifloxacin-associated acute hepatitis. Pharmacotherapy. 2001;21:1579-82. [PMID: 11765309] CrossrefMedlineGoogle Scholar3. Drabo YJ, Niakara A, Ouedraogo H. [Acute pancreatitis secondary to administration or norfloxacin] [Letter]. Ann Fr Anesth Reanim. 2002;21:68-9. [PMID: 11878127] CrossrefMedlineGoogle Scholar4. Mann S, Thillainayagam A. Is ciprofloxacin a new cause of acute pancreatitis? [Letter]. J Clin Gastroenterol. 2000;31:336. [PMID: 11129278] CrossrefMedlineGoogle Scholar5. Mennecier D, Thiolet C, Bredin C, Potier V, Vergeau B, Farret O. [Acute pancreatitis after treatment by levofloxacin and methylprednisolone] [Letter]. Gastroenterol Clin Biol. 2001;25:921-2. [PMID: 11852403] MedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Pittsburgh School of Medicine, Pittsburgh, PA 15213; and Indiana Hospital, Indiana, PA 15701. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCorrection: Gatifloxacin-Induced Hepatotoxicity and Acute Pancreatitis Metrics Cited ByDrug induced pancreatitis: A systematic review of case reports to determine potential drug associationsHepatotoxicity of AntibioticsHepatotoxicity of Antimicrobials and Antifungal AgentsHepatic injury due to drugs, herbal compounds, chemicals and toxinsFluoroquinolones Reported HepatotoxicityDrug-Induced Liver DiseaseGatifloxacinPANCREATITISDrug-induced liver disease 2004Correction: Gatifloxacin-Induced Hepatotoxicity and Acute Pancreatitis 6 January 2004Volume 140, Issue 1Page: 73-74KeywordsAbdominal painAcute pancreatitisAminotransferasesBilirubinBiopsyEdemaLiverLiver fibrosisPhosphatasesUpper respiratory tract infections ePublished: 6 January 2004 Issue Published: 6 January 2004 CopyrightCopyright © 2004 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...