非快速眼动睡眠
睡眠纺锤
脑电图
K-络合物
多导睡眠图
慢波睡眠
听力学
睡眠(系统调用)
心理学
睡眠阶段
快速眼动睡眠
三角波
麻醉
医学
神经科学
计算机科学
操作系统
作者
Mangalam Sankupellay,Stephen J. Wilson,Helen Heussler,Chloe Parsley,Margaret Yuill,Carolyn Dakin
标识
DOI:10.1016/j.clinph.2010.06.030
摘要
This study characterises and describes the maturational evolution of the healthy infant sleep electroencephalogram (EEG) longitudinally from 2 weeks to 24 months of age, by means of power spectral analysis. A prospective cohort of 34 healthy infants underwent overnight polysomnography (PSG) at 2 weeks, and at 3, 6, 12 and 24 months of age. Sleep epochs were scored as Active Sleep (AS) and Quiet Sleep (QS) at 2 weeks of age and as Rapid Eye Movement (REM) and Non-REM (NREM) stages from 3 months onwards. Representative epochs were used to generate the EEG power spectra, from the central C3 derivation. These were analysed visually and quantitatively in AS/REM and QS/NREM sleep in the following bandwidths: delta (0.5–4 Hz); theta (4–8 Hz); alpha (8–11 Hz); sigma (11–15 Hz) and 0.5–25 Hz. Sleep EEG (central derivation) power spectra changed significantly in the different bandwidths as the infants matured. The emergence of a peak in the sigma bandwidth in NREM N2 sleep corresponded with the development of sleep spindles. Maturational changes were also seen in NREM N3 and in theta and alpha bandwidths in both AS/REM and QS/NREM. Sleep EEG power spectra characteristics in healthy infants evolve in keeping with maturation and neurodevelopmental milestones. This study provides an atlas of healthy infant sleep EEG in the early years of life, providing a basis for association with other neurodevelopmental measures and a normative dataset on which disease may be discriminated.
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