细胞凋亡
医学
怀孕
胎盘
男科
末端脱氧核苷酸转移酶
标记法
孕早期
染色
入射(几何)
产科
免疫组织化学
胎儿
病理
生物
遗传学
物理
光学
作者
Stephen C. Smith,Philip N. Baker,E. M. Symonds
标识
DOI:10.1016/s0002-9378(97)70438-1
摘要
OBJECTIVES: The study aims were to conclusively demonstrate apoptosis in the human placenta and to quantify its incidence at different stages of pregnancy. STUDY DESIGN: Placental samples were obtained from 28 first-trimester pregnancies and 38 uncomplicated third-trimester pregnancies. Light microscopy, electron microscopy, and terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate marker nick end-labeling staining were used to identify apoptosis. Light microscopy was used to quantify its incidence. RESULTS: Apoptosis has been conclusively demonstrated within placental tissue. Quantification of apoptosis (medians and interquartile ranges) was as follows: first trimester (n = 28), 0.07% of cells (0.05% to 0.14%); third trimester (n = 39), 0.14% of cells (0.09% to 0.20%). The incidence of apoptosis was significantly higher in the third trimester than in the first trimester (p < 0.01, Mann-Whitney U test). CONCLUSIONS: Placental apoptosis increases significantly as pregnancy progresses, suggesting that it may play a role in the normal development and aging of the placenta.(Am J Obstet Gynecol 1997;177:57-65)
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