室下区
神经母细胞
齿状回
神经科学
冲程(发动机)
病变
纹状体
中棘神经元
嘴侧洄游流
生物
神经元
内生
脑损伤
神经发生
医学
病理
中枢神经系统
细胞生物学
神经干细胞
多巴胺
干细胞
内分泌学
工程类
机械工程
作者
Åke Arvidsson,Tove Collin,Deniz Kirik,Zaal Kokaia,Olle Lindvall
出处
期刊:Nature Medicine
[Springer Nature]
日期:2002-08-05
卷期号:8 (9): 963-970
被引量:2652
摘要
In the adult brain, new neurons are continuously generated in the subventricular zone and dentate gyrus, but it is unknown whether these neurons can replace those lost following damage or disease. Here we show that stroke, caused by transient middle cerebral artery occlusion in adult rats, leads to a marked increase of cell proliferation in the subventricular zone. Stroke-generated new neurons, as well as neuroblasts probably already formed before the insult, migrate into the severely damaged area of the striatum, where they express markers of developing and mature, striatal medium-sized spiny neurons. Thus, stroke induces differentiation of new neurons into the phenotype of most of the neurons destroyed by the ischemic lesion. Here we show that the adult brain has the capacity for self-repair after insults causing extensive neuronal death. If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans.
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