染色质
染色质重塑
表观遗传学
组蛋白密码
生物
组蛋白
组蛋白修饰酶
表观遗传学
组蛋白甲基转移酶
神经发生的表观遗传调控
细胞生物学
组蛋白甲基化
基因表达调控
核小体
遗传学
计算生物学
基因表达
DNA甲基化
基因
作者
Tamaki Suganuma,Jerry L. Workman
标识
DOI:10.1146/annurev-biochem-061809-175347
摘要
Alterations of chromatin structure have been shown to be crucial for response to cell signaling and for programmed gene expression in development. Posttranslational histone modifications influence changes in chromatin structure both directly and by targeting or activating chromatin-remodeling complexes. Histone modifications intersect with cell signaling pathways to control gene expression and can act combinatorially to enforce or reverse epigenetic marks in chromatin. Through their recognition by protein complexes with enzymatic activities cross talk is established between different modifications and with other epigenetic pathways, including noncoding RNAs (ncRNAs) and DNA methylation. Here, we review the functions of histone modifications and their exploitation in the programming of gene expression during several events in development.
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