Serum Levels of Polyunsaturated Fatty Acids and Risk of Colorectal Cancer: A Prospective Study

二十二碳五烯酸 优势比 医学 内科学 置信区间 结直肠癌 多不饱和脂肪酸 六烯酸 胃肠病学 内分泌学 癌症 脂肪酸 生物 生物化学
作者
Masayo Kojima,Kenji Wakai,Shinkan Tokudome,Koji Suzuki,Koji Tamakoshi,Yoshiyuki Watanabe,Miyuki Kawado,Shiori Hashimoto,N Hayakawa,Kotaro Ozasa,Hideaki Toyoshima,Sadao Suzuki,Yoshinori Ito,Akiko Tamakoshi
出处
期刊:American Journal of Epidemiology [Oxford University Press]
卷期号:161 (5): 462-471 被引量:82
标识
DOI:10.1093/aje/kwi066
摘要

To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at –80°C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total ω-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), α-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of ω-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
1秒前
1秒前
shen发布了新的文献求助10
1秒前
沐雨清风发布了新的文献求助10
1秒前
Jasper应助眼睛大的仰采纳,获得10
2秒前
2秒前
铃铃铛发布了新的文献求助10
3秒前
3秒前
berry完成签到,获得积分10
3秒前
4秒前
xuqiansd完成签到,获得积分10
4秒前
4秒前
SYLH应助古往今来采纳,获得30
5秒前
搜集达人应助魔力巴啦啦采纳,获得10
5秒前
5秒前
香蕉觅云应助shanbaibai采纳,获得10
6秒前
6秒前
6秒前
wwx完成签到,获得积分10
6秒前
羊羊羊发布了新的文献求助10
6秒前
6秒前
6秒前
苦哈哈发布了新的文献求助10
8秒前
背后思山完成签到 ,获得积分10
8秒前
七年完成签到,获得积分10
8秒前
小扑棱蛾子完成签到 ,获得积分10
8秒前
zhaosh发布了新的文献求助10
9秒前
9秒前
9秒前
haha完成签到,获得积分10
9秒前
Camellia完成签到,获得积分20
10秒前
飞天意面完成签到,获得积分10
10秒前
喜东东完成签到,获得积分10
10秒前
俭朴的小蘑菇完成签到,获得积分10
11秒前
11秒前
大脸猫爱吃鱼完成签到,获得积分10
11秒前
qys发布了新的文献求助10
11秒前
Zz发布了新的文献求助10
12秒前
Vererg完成签到,获得积分10
13秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 1000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3979122
求助须知:如何正确求助?哪些是违规求助? 3522967
关于积分的说明 11215682
捐赠科研通 3260436
什么是DOI,文献DOI怎么找? 1799990
邀请新用户注册赠送积分活动 878770
科研通“疑难数据库(出版商)”最低求助积分说明 807061