PTEN公司
小RNA
Wnt信号通路
癌症研究
医学
抗药性
前列腺癌
癌症
肿瘤科
外科肿瘤学
生物
乳腺癌
癌变
PI3K/AKT/mTOR通路
内科学
生物信息学
基因
信号转导
遗传学
作者
He-da Zhang,Lin-Hong Jiang,Da-wei Sun,Jian Li,Zhen-ling Ji
出处
期刊:Breast Cancer
[Springer Nature]
日期:2017-05-05
卷期号:24 (4): 521-527
被引量:74
标识
DOI:10.1007/s12282-017-0776-x
摘要
MicroRNAs (miRs) are short and highly conserved non-coding RNAs molecules consisting of 18-25 nucleotides that regulate gene expression at post-transcriptional level by direct binding to complementary binding sites within the 3'untranslated region (3'UTR) of target mRNAs. New evidences have demonstrated that miRNAs play an important role in diverse physiological processes, including regulating cell growth, apoptosis, metastasis, drug resistance, and invasion. In chromosomes 11 and 22 of the miR-130 family, paralogous miRNA sequences, miR-130a and miR-130b are situated, respectively. MiR-130a has participated in different pathogenesis, including hepatocellular carcinoma, cervical cancer, ovarian cancer, glioblastoma, prostate carcinoma, leukemia, etc. Most important of all, more and more evidences indicate that miR-130a is associated with drug resistance and acts as an intermediate in PI3 K/Akt/PTEN/mTOR, Wnt/β-catenin and NF-kB/PTEN drug resistance signaling pathways. Drug resistance has emerged as a major obstacle to successful treatment of cancer nowadays and in this review, we will reveal the function of miR-130a in cancer, especially in drug resistance. Therefore, it will provide a new therapeutic target for the treatment of cancer, especially in chemotherapy.
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