花椒
结肠炎
芦丁
TLR4型
槲皮素
药理学
化学
芸香科
炎症性肠病
传统医学
生物
医学
信号转导
生物化学
免疫学
植物
内科学
抗氧化剂
疾病
作者
Zecai Zhang,Jiuxi Liu,Peng Shen,Yongguo Cao,Xiaojie Lu,Xuejiao Gao,Yunhe Fu,Bo Liu,Naisheng Zhang
标识
DOI:10.1016/j.intimp.2016.10.021
摘要
Zanthoxylum bungeanum, which belongs to the Zanthoxylum genus of the Rutaceae family, is now wildly distributed in most parts of China and some Southeast Asian countries. The pericarp of Zanthoxylum bungeanum has been known to exhibit antibacterial, anti-inflammatory and other important therapeutic activities. The purpose of this study was to investigate the effects and mechanisms of Zanthoxylum bungeanum pericarp extract (ZBE) on DSS-induced experimental colitis in mice. The results demonstrated that the major flavonoid composition of ZBE includes rutin (32.36%), quercetin (13.61%) and isoquercitrin (24.89%). ZBE alleviated DSS-induced body weight loss, colon length shortening and colonic pathological damage. Furthermore, ZBE inhibited the expression of TNF-α, IL-1β and IL-12 via the regulation of TLR4 and TLR4-related pathways in DSS-induced experimental colitis in mice and LPS-triggered inflammation in J774.1 cells. Our findings suggest that ZBE is effective in ameliorating experimental colitis, and further investigation is necessary on the use of ZBE as a new dietary strategy to lower the risk of ulcerative colitis (UC).
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