Simultaneous Measurement of In vivo and Transit Mid-Plane Doses with Ionization Chambers in Gynecological Malignancy Patients Undergoing Three-Dimensional Conformal Radiotherapy.

Purpose: The aim of this study is to estimate delivered radiation doses inside planning tumor volume (PTV) using the in vivo (mid-plane dose) measurement and transit measurement methods in gynecological malignancy patients undergoing three-dimensional conformal radiotherapy (3DCRT) using calibrated ionization chambers. Materials and Methods: Six patients with histopathologically proven carcinoma of the cervix or endometrium were planned with four-field 3DCRT to the pelvic site. Isocenter was at the geometric mid-plane of PTV with a dose prescription of 50 Gy in 25 fractions. Clinical mid-plane dose (Diso,Transit) estimates were done in one method (transit) using the FC-65 positioned at electronic portal imaging device level. In another method, a repeat computerized tomography scan was performed (at the 11th fraction) using CC-13 having a protective cap in the vaginal cavity for in vivo measurements (Din vivo). Simultaneous measurements were performed with the two chambers from the 11th fraction onward at least 3–4 times during the remaining course of treatment. Results: The agreement of mean doses from these two described methods and treatment planning system reference doses was in the range of −4.4 ± 1.1% (minimum) to −0.3 ± 2.0% (maximum) and −4.0 ± 1.7% (minimum) to 1.9 ± 2.4% for Dinvivoand Diso,Transit, respectively, which are an acceptable range of daily radiation dose delivery. Conclusion: The fundamental importance of this study lies in simultaneous validation of delivered dose in real time with two methods. A study in this small number of patients has given the confidence to apply transit measurements for quality assurance on a routine basis as an accepted clinical dosimetry for the selected patients.