Distinguishing between COVID‐19 and influenza during the early stages by measurement of peripheral blood parameters

病毒学 2019年冠状病毒病(COVID-19) 严重急性呼吸综合征冠状病毒2型(SARS-CoV-2) 2019-20冠状病毒爆发 外周血 倍他科诺病毒 医学 生物 免疫学 病理 传染病(医学专业) 爆发 疾病
作者
Jiangnan Chen,Yong Pan,Gangfeng Li,Wenfang Xu,Lihong Zhang,Shijin Yuan,Yan Xia,Pei Lu,Jun Zhang
出处
期刊:Journal of Medical Virology [Wiley]
卷期号:93 (2): 1029-1037 被引量:39
标识
DOI:10.1002/jmv.26384
摘要

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 infection. This study aims to examine the changes in peripheral blood parameters during the early stages of COVID-19 and influenza. We analyzed the peripheral blood parameters of 169 COVID-19 patients and 131 influenza patients during the early-onset stage. Results from the patients with COVID-19 were compared with those from healthy controls and influenza patients. In addition, results from patients with common and severe COVID-19 were further compared. There were significant differences between COVID-19 and influenza patients in terms of age, white blood cell count, platelet count, percentage of neutrophils, percentage of lymphocytes, percentage of monocytes, percentage of eosinophils, percentage of basophils, neutrophil, count and monocyte count. Two parameters (monocyte count and percentage of basophils) were combined to clarify the diagnostic efficacy of COVID-19 and influenza and the area under the curve was found to be 0.772. Comparison of peripheral blood parameters from common COVID-19, severe COVID-19, and influenza patients revealed many differences during the early disease stages. The diagnostic formula developed by this study will be of benefit for physicians in the differentiation of COVID-19 and influenza.

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