SGLT2 INHIBITORS ARE NOT ASSOCIATED WITH RISKS FOR AMPUTATION-A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Sodium glucose cotransporter-2(SGLT2) inhibitors are an insulin-independent class of oral anti-hyperglycemic medication with promising cardiovascular and renal outcome benefits. One of its safety concerns is a perceived increase in the risk of lower extremity amputation, mainly put forth by the