姜黄素
生物利用度
壳聚糖
脂质体
化学
保健品
鼠李糖脂
色谱法
食品科学
生物化学
药理学
医学
遗传学
生物
细菌
铜绿假单胞菌
作者
Wei Zhou,Ce Cheng,Li Ma,Liqiang Zou,Wei Liu,Ruyi Li,Yupo Cao,Yuhuan Liu,Roger Ruan,Jihua Li
出处
期刊:Molecules
[MDPI AG]
日期:2021-01-21
卷期号:26 (3): 560-560
被引量:30
标识
DOI:10.3390/molecules26030560
摘要
There is growing interest in developing biomaterial-coated liposome delivery systems to improve the stability and bioavailability of curcumin, which is a hydrophobic nutraceutical claimed to have several health benefits. The curcumin-loaded rhamnolipid liposomes (Cur-RL-Lips) were fabricated from rhamnolipid and phospholipids, and then chitosan (CS) covered the surface of Cur-RL-Lips by electrostatic interaction to form CS-coated Cur-RL-Lips. The influence of CS concentration on the physical stability and digestion of the liposomes was investigated. The CS-coated Cur-RL-Lips with RL:CS = 1:1 have a relatively small size (412.9 nm) and positive charge (19.7 mV). The CS-coated Cur-RL-Lips remained stable from pH 2 to 5 at room temperature and can effectively slow the degradation of curcumin at 80 °C; however, they were highly unstable to salt addition. In addition, compared with Cur-RL-Lips, the bioavailability of curcumin in CS-coated Cur-RL-Lips was relatively high due to its high transformation in gastrointestinal tract. These results may facilitate the design of a more efficacious liposomal delivery system that enhances the stability and bioavailability of curcumin in nutraceutical-loaded functional foods and beverages.
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