The topological phase transition between normal and topological insulators is essential in topological mechanism analysis and search for new topological materials. Herein, on the basis of the well‐known monolayer 2D topological insulator 1T′‐WTe 2 , a new 2D material 1T′‐WSTe is constructed. It is a typical central inversion asymmetric 2D topological insulator. The fascinating feature of this material is that its low‐energy electronic structure is very similar to the inversion broken topological phase transition point. The first‐principles calculations reveal that the ±4% uniaxial strain can effectively turn the 2D material into topological insulator or normal insulator phases.