材料科学
原子层沉积
阳极氧化
生物相容性
结晶
氧化物
图层(电子)
化学工程
钛
纳米技术
表面改性
氧化钛
涂层
复合材料
铝
冶金
工程类
作者
Martin Motola,Jan Čapek,Raúl Zazpe,Jana Báčová,Luděk Hromádko,Lenka Brůčková,Siowwoon Ng,Jiří Handl,Zdeněk Spotz,Petr Knotek,Kaushik Baishya,Pavlína Majtnerová,Jan Přikryl,Hanna Sopha,Tomáš Roušar,Jan M. Macák
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2020-08-18
卷期号:3 (9): 6447-6456
被引量:32
标识
DOI:10.1021/acsabm.0c00871
摘要
The present work exploits Ti sheets and TiO2 nanotube (TNT) layers and their surface modifications for the proliferation of different cells. Ti sheets with a native oxide layer, Ti sheets with a crystalline thermal oxide layer, and two kinds of TNT layers (prepared via electrochemical anodization) with a defined inner diameter of 12 and 15 nm were used as substrates. A part of the Ti sheets and the TNT layers was additionally coated by thin TiO2 coatings using atomic layer deposition (ALD). An increase in cell growth of WI-38 fibroblasts (>50%), MG-63 osteoblasts (>30%), and SH-SY5Y neuroblasts (>30%) was observed for all materials coated by five cycles ALD compared to their uncoated counterparts. The additional ALD TiO2 coatings changed the surface composition of all materials but preserved their original structure and protected them from unwanted crystallization and shape changes. The presented approach of mild surface modification by ALD has a significant effect on the materials' biocompatibility and is promising toward application in implant materials.
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