臂旁核
神经科学
核心
臂旁外侧核
心理学
沟通
生物
作者
Michael Chiang,Eileen Nguyen,Martha Canto-Bustos,Andrew E. Papale,Anne-Marie M. Oswald,Sarah E. Ross
出处
期刊:Neuron
[Elsevier]
日期:2020-06-01
卷期号:106 (6): 927-939.e5
被引量:138
标识
DOI:10.1016/j.neuron.2020.03.014
摘要
The lateral parabrachial nucleus (lPBN) is a major target of spinal projection neurons conveying nociceptive input into supraspinal structures. However, the functional role of distinct lPBN efferents in diverse nocifensive responses have remained largely uncharacterized. Here we show that that the lPBN is required for escape behaviors and aversive learning to noxious stimulation. In addition, we find that two populations of efferent neurons from different regions of the lPBN collateralize to distinct targets. Activation of efferent projections to the ventromedial hypothalamus (VMH) or lateral periaqueductal gray (lPAG) drives escape behaviors, whereas activation of lPBN efferents to the bed nucleus stria terminalis (BNST) or central amygdala (CEA) generates an aversive memory. Finally, we provide evidence that dynorphin-expressing neurons, which span cytoarchitecturally distinct domains of the lPBN, are required for aversive learning.
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