Bone mineral density and osteoporosis in relation to all-cause and cause-specific mortality in NHANES: A population-based cohort study

骨矿物 医学 全国健康与营养检查调查 危险系数 骨质疏松症 转子 比例危险模型 队列 人口 股骨 置信区间 股骨颈 死亡率 髋部骨折 队列研究 内科学 外科 环境卫生
作者
Shaofang Cai,Jiayao Fan,Li Zhu,Jianhong Ye,Xianming Rao,Chunhong Fan,Yaohong Zhong,Yingjun Li
出处
期刊:Bone [Elsevier]
卷期号:141: 115597-115597 被引量:44
标识
DOI:10.1016/j.bone.2020.115597
摘要

The majority of the published studies ascertaining the relationships between low bone mineral density (BMD) and mortality highlighted the elderly population with limited sample size. Our study aimed to ascertain the relationships in general population. This study ascertained the relationships between BMD levels in femur and lumbar spine with all-cause and cause-specific mortality in the National Health and Nutrition Examination Survey (NHANES) (n = 15,076, mean age 48.6 years). Cox proportional hazards models were adopted to calculate the hazard ratios (HR) and the corresponding 95% confidence intervals (CIs) for mortality. During a 6.8-year median follow-up, 1216 men and women in the cohort died. There was a higher risk of all-cause mortality among participants with osteoporosis compared with normal in the regions of total femur (HR = 1.36, 95% CI = 1.07–1.73), femur neck (HR = 1.41, 95% CI = 1.11–1.78), intertrochanter (HR = 1.34, 95% CI = 1.05–1.72), as well as overall (HR = 1.36, 95% CI = 1.09–1.69). Non-linear dose-response analyses showed a statistically significant L-shaped association for all-cause mortality with BMD increment in the regions of total femur, femur neck, trochanter, and intertrochanter. The protective role of higher BMD level in femur for decreased risk of cancer mortality and heart diseases mortality was more evident in male participants and female participants, respectively. In summary, our results revealed that maintaining normal BMD is critical to lower the risk of mortality. The association between higher BMD level in femur and decreased risk of cancer as well as heart diseases mortality varies by gender.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
书生也要读书完成签到,获得积分10
刚刚
赖向珊发布了新的文献求助10
1秒前
jam完成签到,获得积分10
2秒前
4秒前
酷酷行天完成签到,获得积分20
4秒前
昵称有敏感词完成签到,获得积分10
5秒前
甜甜妙梦发布了新的文献求助10
5秒前
哈哈哈发布了新的文献求助10
6秒前
eee丶peng完成签到,获得积分20
7秒前
LF发布了新的文献求助10
7秒前
张豪杰完成签到 ,获得积分10
7秒前
jam发布了新的文献求助10
7秒前
7秒前
CipherSage应助whl采纳,获得10
7秒前
wu完成签到 ,获得积分10
8秒前
shaguodoufutang关注了科研通微信公众号
9秒前
情怀应助高lucky采纳,获得10
9秒前
ynwamo完成签到,获得积分10
9秒前
单纯大侠完成签到,获得积分10
9秒前
max完成签到 ,获得积分10
11秒前
12秒前
王肖发布了新的文献求助10
12秒前
ddd完成签到,获得积分10
12秒前
LF完成签到,获得积分10
12秒前
爱听歌的依秋完成签到,获得积分10
12秒前
落后的翠柏完成签到 ,获得积分10
13秒前
eee丶peng发布了新的文献求助30
14秒前
梦~完成签到,获得积分10
14秒前
14秒前
PCT完成签到,获得积分10
15秒前
15秒前
16秒前
科研通AI2S应助单纯大侠采纳,获得10
17秒前
uniphoton发布了新的文献求助10
18秒前
别皱眉完成签到,获得积分10
18秒前
洪山老狗完成签到,获得积分10
18秒前
19秒前
19秒前
weijian完成签到,获得积分10
20秒前
高分求助中
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
Retention of title in secured transactions law from a creditor's perspective: A comparative analysis of selected (non-)functional approaches 500
"Sixth plenary session of the Eighth Central Committee of the Communist Party of China" 400
Introduction to Modern Controls, with illustrations in MATLAB and Python 310
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3056892
求助须知:如何正确求助?哪些是违规求助? 2713451
关于积分的说明 7435856
捐赠科研通 2358580
什么是DOI,文献DOI怎么找? 1249424
科研通“疑难数据库(出版商)”最低求助积分说明 607055
版权声明 596283