透明质酸酶
解聚
渗透(战争)
药物输送
基质
透明质酸
癌症研究
化学
纳米颗粒
医学
酶
病理
材料科学
纳米技术
生物化学
免疫组织化学
运筹学
有机化学
工程类
解剖
作者
Daniel H.S. Brundel,Orlagh M. Feeney,Cameron J. Nowell,Estelle J.A. Suys,Gracia Gracia,Lisa M. Kaminskas,Michelle M. McIntosh,Dong Hyun Kang,Christopher John Porter
出处
期刊:Nanomedicine
日期:2021-02-01
卷期号:16 (4): 275-292
被引量:5
标识
DOI:10.2217/nnm-2020-0433
摘要
Aim: Delivery of nanoparticles (NPs) to tumors can be impeded by high levels of hyaluronan (HA) in the stroma. Enzymatic depolymerization of HA with PEGylated hyaluronidase (PEGPH20) improves the delivery of antibodies to tumors. However, it is unknown whether NP delivery is enhanced by this strategy. Methods: The impact of PEGPH20 pretreatment on the uptake and tumor penetration of model PEGylated polystyrene NPs was studied in mice with orthotopic breast cancers. Results: Tumor oxygenation and NP penetration, but not overall tumor uptake, of 50 nm NPs, was significantly enhanced by PEGPH20 pre-administration. Conclusion: PEGPH20 has the potential to improve intratumoral penetration of NP-based drug delivery systems and enhance access to cancer cells in poorly vascularized regions of the tumor.
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