Ripened Pu-erh Tea Extract Promotes Gut Microbiota Resilience against Dextran Sulfate Sodium Induced Colitis

结肠炎 失调 肠道菌群 促炎细胞因子 微生物学 炎症性肠病 炎症 免疫学 生物 药理学 内科学 化学 医学 疾病
作者
Yina Huang,Qin Yang,Xuan Mi,Liang Qiu,Xueying Tao,Zhihong Zhang,Jun Xia,Qinglong Wu,Hua Wei
出处
期刊:Journal of Agricultural and Food Chemistry [American Chemical Society]
卷期号:69 (7): 2190-2203 被引量:49
标识
DOI:10.1021/acs.jafc.0c07537
摘要

Ripened Pu-erh tea (RPT) has been shown to be an effective natural ingredient to defend against experimentally induced colitis. We hypothesized that RPT would alleviate dextran sulfate sodium (DSS) induced colitis via modulating intestinal microbiota. The effect of RPT on mice gut microbiota was evaluated using 16S rRNA gene amplicon sequencing, broad-spectrum antibiotic (ABX) treatment, and fecal microbiota transplantation (FMT). Pretreatment with RPT enhanced intestinal barrier function, reduced colonic and serum proinflammatory cytokine and macrophage infiltration, and preserved the resilience of gut microbiota in mice during a DSS challenge. Administration of either RPT-regulated or healthy control-derived gut microbiota showed similar protection against colitis, and such protection could not be recapitulated with fecal microbiota from ABX-treated mice, suggesting a key role of protective consortium in the disease protection. Mechanistically, cecal contents of short-chain fatty acids (SCFAs) and colonic peroxisome proliferator activated receptor-γ (PPAR-γ) expression in colitis mice increased significantly by RPT intervention. Collectively, RPT treatment improved DSS-induced colitis by partially reversing the dysbiosis state of gut microbiota, which might be associated with an increase in SCFA level and PPAR-γ expression.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
炙热的又夏完成签到,获得积分10
2秒前
cc发布了新的文献求助10
2秒前
顾矜应助五月拾旧采纳,获得10
2秒前
畅快的书包完成签到,获得积分10
3秒前
Wang完成签到,获得积分10
3秒前
colddie完成签到,获得积分10
5秒前
大个应助aliuliu采纳,获得30
10秒前
蓝天海完成签到,获得积分0
10秒前
赘婿应助五五哥采纳,获得10
10秒前
汉堡包应助欣喜成仁采纳,获得10
10秒前
10秒前
12秒前
12秒前
科研小白完成签到,获得积分10
13秒前
13秒前
愿如大卫完成签到,获得积分10
14秒前
15秒前
七濑完成签到,获得积分10
17秒前
18秒前
平平发布了新的文献求助10
18秒前
19秒前
不配.应助大约在冬季采纳,获得20
19秒前
20秒前
20秒前
21秒前
21秒前
22秒前
哈哈哈哈哈哈完成签到,获得积分10
22秒前
愿如大卫发布了新的文献求助10
22秒前
二六发布了新的文献求助10
24秒前
applepie完成签到,获得积分10
24秒前
25秒前
疯狂的虔发布了新的文献求助10
26秒前
热心依风发布了新的文献求助10
27秒前
27秒前
28秒前
yatou5651应助leafye采纳,获得30
28秒前
31秒前
Jasper应助112采纳,获得10
31秒前
Shalnark完成签到,获得积分10
32秒前
高分求助中
歯科矯正学 第7版(或第5版) 1004
SIS-ISO/IEC TS 27100:2024 Information technology — Cybersecurity — Overview and concepts (ISO/IEC TS 27100:2020, IDT)(Swedish Standard) 1000
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Semiconductor Process Reliability in Practice 720
GROUP-THEORY AND POLARIZATION ALGEBRA 500
Mesopotamian divination texts : conversing with the gods : sources from the first millennium BCE 500
Days of Transition. The Parsi Death Rituals(2011) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3232979
求助须知:如何正确求助?哪些是违规求助? 2879598
关于积分的说明 8212194
捐赠科研通 2547147
什么是DOI,文献DOI怎么找? 1376549
科研通“疑难数据库(出版商)”最低求助积分说明 647659
邀请新用户注册赠送积分活动 623067