神经导管
神经再支配
坐骨神经
电气导管
周围神经损伤
神经外膜修复
医学
再生(生物学)
神经损伤
生物医学工程
材料科学
外科
解剖
生物
工程类
细胞生物学
机械工程
作者
Dong Hoon Lee,Arjun K. Fontaine,Xianzhong Meng,Dae‐Won Park
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2016-07-15
卷期号:2 (8): 1403-1410
被引量:39
标识
DOI:10.1021/acsbiomaterials.6b00344
摘要
Although the gold standard for the surgical treatment of peripheral nerve injury, the autograft is associated with many drawbacks, including a second surgical procedure, donor site morbidity, mismatch of donor nerve size, and limited donor nerve length. As an alternative to the autograft, nerve guidance conduits may be used to promote neuronal growth and guide axonal extension after nerve injury. Using a blend of RGD-conjugated polyurea and polycaprolactone, a nerve guidance conduit was designed consisting of intraluminal microchannels with aligned nanofibers. A 10 mm sciatic nerve transection rat model was used to evaluate the efficacy of the conduit up to 8 weeks after nerve transection and conduit implantation. Restoration of electrophysiological activity from the nerve guidance conduit was significantly improved compared to the autograft. Functional and histological assessments indicated that the nerve guidance conduit is comparable to autograft in functional recovery and target muscle reinnervation, respectively.
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