Design and Synthesis of Novel 2-(1,2,4-triazol-1-yl)-quinoline-Based Tricyclic 1,5-benzothiazepine Derivatives

A series of new tricyclic 1,5-benzothiazepine derivatives containing 2-(1,2,4-triazol-1-yl)quinoline were synthesized by the reaction of 1,5-benzothiazepine with benzohydroximinoyl chlorides via 1,3-dipolar cycloaddition reaction. The structures of the target compounds were confirmed by IR, 1H NMR, MS, elemental, and X-ray crystallographic analysis.