医学
前列腺癌
前列腺切除术
淋巴结
正电子发射断层摄影术
放射科
组织病理学
解剖(医学)
PET-CT
核医学
淋巴
癌症
病理
内科学
作者
Annika Herlemann,Vera Wenter,Alexander Kretschmer,Kolja M. Thierfelder,Peter Bartenstein,Claudius Faber,Franz‐Josef Gildehaus,Christian G. Stief,Christian Gratzke,Wolfgang P. Fendler
标识
DOI:10.1016/j.eururo.2015.12.051
摘要
We evaluated the accuracy of 68Ga-prostate-specific membrane antigen-HBED-CC (68Ga-PSMA) positron emission tomography/computed tomography (PET/CT) for nodal staging prior to lymph node dissection (LND) in patients with prostate cancer (PCa). Thirty-four patients with histologically proven PCa underwent 68Ga-PSMA-HBED-CC PET/CT prior to radical prostatectomy with primary LND (pLND; n = 20) and PET/CT prior to secondary LND (sLND; n = 14). Accuracy of PET and CT were analysed separately for staging of the following 71 lymph node (LN) regions: pelvic left (n = 30), pelvic right (n = 31), presacral (n = 3), and para-aortic (n = 7). Postoperative histopathology was taken as a reference standard. Thirty-seven of 71 (52%) regions showed LN metastases on histopathology. Sensitivity, specificity, positive predictive value, and negative predictive value for detection of LN metastases were 84%, 82%, 84%, and 82% for PET criteria and 65%, 76%, 75%, and 67% for CT criteria. PET was more accurate for nodal staging compared with CT both at pLND (88% vs 75%) and sLND (77% vs 65%). Overall, 68Ga-PSMA PET/CT provides accurate nodal staging prior to pLND and sLND for PCa. 68Ga-PSMA positron emission tomography/computed tomography is accurate in detecting tumour spread to lymph nodes before patients undergo surgery for prostate cancer.
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