孟德尔遗传
家族性高胆固醇血症
疾病
孟德尔随机化
冠状动脉疾病
冲程(发动机)
遗传学
心肌梗塞
风险因素
家族史
家庭聚集
医学
生物信息学
生物
内科学
遗传变异
基因
胆固醇
工程类
基因型
机械工程
作者
Aldons J. Lusis,Rebecca Mar,Päivi Pajukanta
出处
期刊:Annual Review of Genomics and Human Genetics
[Annual Reviews]
日期:2004-09-22
卷期号:5 (1): 189-218
被引量:341
标识
DOI:10.1146/annurev.genom.5.061903.175930
摘要
▪ Abstract Atherosclerosis, the primary cause of coronary artery disease (CAD) and stroke, is a disorder with multiple genetic and environmental contributions. Genetic-epidemiologic studies have identified a surprisingly long list of genetic and nongenetic risk factors for CAD. However, such studies indicate that family history is the most significant independent risk factor ( 15 , 52 , 77 ). Many Mendelian disorders associated with atherosclerosis, such as familial hypercholesterolemia (FH), have been characterized, but they explain only a small percentage of disease susceptibility (although a substantial fraction of early CAD). Most cases of myocardial infarction (MI) and stroke result from the interactions of multiple genetic and environmental factors, none of which can cause disease by itself. Successful discovery of these genetic factors will require using complementary approaches with animal models, large-scale human genetic studies, and functional experiments. This review emphasizes the common, complex forms of CAD.
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