COP9信号体
生物
蛋白酶体
光形态发生
细胞生物学
泛素
蛋白质水解
遗传学
拟南芥
基因
生物化学
肽水解酶类
突变体
酶
蛋白酶
作者
Giovanna Serino,Xing‐Wang Deng
标识
DOI:10.1146/annurev.arplant.54.031902.134847
摘要
The COP9 signalosome (CSN) is a multiprotein complex that was initially identified in plants as a repressor of photomorphogenesis. It is now known to play major roles in several other developmental pathways, from auxin response to flower development. Furthermore, the COP9 signalosome shares homologies with the lid sibcomplex of the proteasome and is evolutionarily conserved from fission yeast to humans. It is important for the proper development of virtually all higher eukaryotes. In recent years, significant progress has been made in unraveling the molecular, cellular, and physiological mode of action of the COP9 signalosome. This review discusses our current understanding of the COP9 signalosome function with particular emphasis on its recently defined role in modulating a wide variety of cellular processes by regulating specific protein degradation events.
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