癌症研究
抑制器
髓源性抑制细胞
癌症
肝内胆管癌
髓系细胞
髓样
花生四烯酸5-脂氧合酶
医学
生物
内科学
生物化学
酶
花生四烯酸
作者
Yuli Lin,Qian Cai,Yu Chen,Tiancong Shi,Weiren Liu,Mao Li,Bo Deng,Zhen Ying,Yuan Gao,Haoyang Luo,Xuguang Yang,Xiaowu Huang,Ying‐Hong Shi,Rui He
出处
期刊:Hepatology
[Lippincott Williams & Wilkins]
日期:2021-08-13
卷期号:75 (1): 28-42
被引量:164
摘要
Our study reveals a role for CAFs in orchestrating the optimal cancer stemness-enhancing microenvironment by educating MDSCs, and suggests the 5-LO/LTB4-BLT2 axis as promising therapeutic targets for ICC chemoresistance by targeting cancer stemness.
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