Target-Triggered Nanomaterial Self-Assembly Induced Electromagnetic Hot-Spot Generation for SERS–Fluorescence Dual-Mode In Situ Monitoring MiRNA-Guided Phototherapy

化学 荧光 双模 纳米技术 荧光寿命成像显微镜 纳米颗粒 纳米医学 拉曼光谱 生物物理学 光学 材料科学 生物 物理 工程类 航空航天工程
作者
Jiwei Wang,Caiyi Zhang,Zhao Liu,Shibao Li,Ping Ma,Fenglei Gao
出处
期刊:Analytical Chemistry [American Chemical Society]
卷期号:93 (41): 13755-13764 被引量:49
标识
DOI:10.1021/acs.analchem.1c01338
摘要

A multifunctional theranostic nanosystem that integrates dynamic monitoring and therapeutic functions is necessary for precision tumor medicine. Herein, an entropy-driven self-assembly nanomachine is developed that overcomes the mechanism differences of different diagnostic modes and is applied to miRNA surface-enhanced Raman scattering (SERS)–fluorescence dual-mode dynamic monitoring and synergy phototherapy. It is worth noting that the activated dual-mode theranostic nanosystem (DTN) is capable of tumor in situ fluorescence imaging and SERS absolute quantification of the target. After being internalized into tumor cells, the DTN nanosystem is activated by the DNA cascade chain displacement of the target miR-21, resulting in the secondary release of fluorophores and the assembly of core–satellite structures (CS structures). The coupling of localized surface plasmon resonances (LSPRs) in the CS structure results in the formation of numerous enhanced electric fields (hot spot) in the nanogap of the CS structure. Then the DTN nanosystem greatly improves the sensitivity and repeatability of Raman detection by converting trace targets into numerous adenines residing in the electromagnetic hot spot of the CS structure. Meanwhile, the CS structure and the loaded photosensitizer are used for synergy phototherapy under the guidance of fluorescence imaging. This proposed strategy is confirmed by in vivo and in vitro results, and it provides new ideas for tumor SERS–fluorescence dual-mode diagnosis and effective tumor therapy.
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