Abstract Recently, MXenes stand out as an attractive type of two-dimensional layered material. Their unique deformable surface terminations and rich chemical compositions endow MXenes with adjustable and customizable characteristics, resulting in excellent linear/non-linear electromagnetic wave responses and versatile applications. In order to get more insights in this area, here, we make a comprehensive summarization of the interactions according to the response principles between MXenes and electromagnetic waves, such as absorption, scattering, emission, transmission, resonance, etc. The latest progress of corresponding applications is also introduced in detail, including photothermal conversion, photo-/photoelectro-catalysis, electromagnetic interference shielding, photoluminescence, tumor therapy, transparent electrode, photodetector, surface-enhanced Raman scattering, plasmonic absorption, saturated absorption, etc. Finally, the challenges and opportunities are discussed to look forward to the beautiful future of MXenes and MXene-based electromagnetic wave responses.