The Association between Dietary Inflammatory Index and Sex Hormones among Men in the United States

No AccessJournal of UrologyAdult Urology1 Jul 2021The Association between Dietary Inflammatory Index and Sex Hormones among Men in the United States Chichen Zhang, Haiyang Bian, Zeyu Chen, Bowen Tian, Haoyuan Wang, Xiang Tu, Boyu Cai, Kun Jin, Xiaonan Zheng, Lu Yang, and Shi Qiu Chichen ZhangChichen Zhang Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China West China School of Clinical Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China Equal study contribution. More articles by this author , Haiyang BianHaiyang Bian Peking University School of Public Health, Institute of Reproductive and Child Health and Department of Epidemiology and Biostatistics, Beijing, China Equal study contribution. More articles by this author , Zeyu ChenZeyu Chen Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China Equal study contribution. More articles by this author , Bowen TianBowen Tian West China School of Clinical Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China More articles by this author , Haoyuan WangHaoyuan Wang West China School of Clinical Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China More articles by this author , Xiang TuXiang Tu Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author , Boyu CaiBoyu Cai Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author , Kun JinKun Jin Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author , Xiaonan ZhengXiaonan Zheng Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author , Lu YangLu Yang †Correspondence: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, No. 37, Guoxue Ln., Chengdu, Sichuan 610041, China telephone: +86 18180610258; FAX: 028-85582944; E-mail Address: [email protected] Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author , and Shi QiuShi Qiu † E-mail Address: [email protected] Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China Center of Biomedical big data, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001703AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: This study investigated the association between Dietary Inflammatory Index and sex hormones in a large, nationally representative adult male sample. Materials and Methods: We utilized data from the 2013–2014 and 2015–2016 National Health and Nutrition Examination Survey. Males aged ≥20 years who provided a 24-hour dietary intake history and underwent serum sex hormone testing were included in analysis. Weighted proportions and multivariable analysis controlling for age, race, energy, smoking status, education level, body mass index and time of venipuncture were used to evaluate the associations between Dietary Inflammatory Index and sex hormones. Results: For 4,151 participants, Dietary Inflammatory Index ranged from −5.05 to 5.48. Mean±SD total testosterone was 419.30±176.27 ng/dl. Mean±SD total testosterone was lower among men in the highest tertile compared with men in the lowest tertile group (410.42±171.97 vs 422.71±175.69, p <0.001). A per unit increase in Dietary Inflammatory Index was related to 4.0% (95% CI 0.5–7.6) higher odds of testosterone deficiency. In the fully adjusted multivariable model, males in Dietary Inflammatory Index tertile 3 (the most pro-inflammatory) had 29.6% (3.1–63.0) higher odds of testosterone deficiency than those in tertile 1 (p trend=0.025). Interaction tests revealed no significant effect of body mass index on the association of Dietary Inflammatory Index with testosterone deficiency and all sex hormone parameters. Conclusions: Men adhering to a more pro-inflammatory diet appear to have a higher risk of testosterone deficiency, indicating the important role of diet in male reproductive health. REFERENCES 1. : The effects of diet on circulating sex hormone levels in men. Nutr Res Rev 2000; 13: 159. Google Scholar 2. : Prevalence and incidence of androgen deficiency in middle-aged and older men: estimates from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 2004; 89: 5920. Google Scholar 3. : The practical management of testosterone deficiency in men. Nat Rev Urol 2015; 12: 641. 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Google Scholar This work was supported by the National Natural Science Foundation of China (Grants 81902578, 81974098, 81974099), the National Key Research and Development Program of China (Grant SQ2017YFSF090096), China Postdoctoral Science Foundation (2017M612971), Post-Doctoral Science Research Foundation of Sichuan University (2020SCU12041), Post-Doctor Research Project, West China Hospital, Sichuan University (2018HXBH085), and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University (Z2018C01). SQ and LY are responsible for the conception and design of the study. SQ, HB, XZ and KJ interpreted the analysis. CZ, ZC, BT, HYW, XT and BC were responsible for the acquisition of data. CZ and HB wrote the first draft of the manuscript and interpreted the data and wrote the final version. All authors critically revised the Article for important intellectual content and approved the final version. LY obtained public funding. Editor's Note: This article is the third of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 179 and 180. © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue 1July 2021Page: 97-103Supplementary Materials Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.Keywordsinflammationdiettestosteronegonadal steroid hormonesdeficiency diseasesAcknowledgmentsThe authors acknowledge Ian Charles Tobias for reviewing the manuscript. The authors thank Drs. Chi Chen, Changzhong Chen and Xing-Lin Chen for providing statistical methodology consultation.MetricsAuthor Information Chichen Zhang Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China West China School of Clinical Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China Equal study contribution. More articles by this author Haiyang Bian Peking University School of Public Health, Institute of Reproductive and Child Health and Department of Epidemiology and Biostatistics, Beijing, China Equal study contribution. More articles by this author Zeyu Chen Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China Equal study contribution. More articles by this author Bowen Tian West China School of Clinical Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China More articles by this author Haoyuan Wang West China School of Clinical Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China More articles by this author Xiang Tu Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author Boyu Cai Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author Kun Jin Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author Xiaonan Zheng Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China More articles by this author Lu Yang Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China †Correspondence: Department of Urology, Institute of Urology, West China Hospital, Sichuan University, No. 37, Guoxue Ln., Chengdu, Sichuan 610041, China telephone: +86 18180610258; FAX: 028-85582944; E-mail Address: [email protected] More articles by this author Shi Qiu Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China Center of Biomedical big data, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China † E-mail Address: [email protected] More articles by this author Expand All This work was supported by the National Natural Science Foundation of China (Grants 81902578, 81974098, 81974099), the National Key Research and Development Program of China (Grant SQ2017YFSF090096), China Postdoctoral Science Foundation (2017M612971), Post-Doctoral Science Research Foundation of Sichuan University (2020SCU12041), Post-Doctor Research Project, West China Hospital, Sichuan University (2018HXBH085), and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University (Z2018C01). SQ and LY are responsible for the conception and design of the study. SQ, HB, XZ and KJ interpreted the analysis. CZ, ZC, BT, HYW, XT and BC were responsible for the acquisition of data. CZ and HB wrote the first draft of the manuscript and interpreted the data and wrote the final version. All authors critically revised the Article for important intellectual content and approved the final version. LY obtained public funding. Editor's Note: This article is the third of 5 published in this issue for which category 1 CME credits can be earned. Instructions for obtaining credits are given with the questions on pages 179 and 180. Advertisement Loading ...