Nickel‐Catalyzed Aminofluoroalkylation of Alkenes: Access to Difluoroalkylated N‐Containing Heterocyclic Compounds

Abstract A nickel‐catalyzed aminofluoroalkylative cyclization of unactive alkenes with iododifluoromethyl ketones was developed to construct versatile difluoroalkylated Nitrogen‐containing heterocycles including aziridines, pyrrolidines and piperidines in moderate to high yields. This method features a broad substrate scope and has been demonstrated on gram scale.