病毒学
肝细胞癌
乙型肝炎病毒
HBx公司
免疫学
乙型肝炎
发病机制
免疫系统
病毒复制
医学
肝硬化
抗原
病毒
丁型肝炎病毒
病毒性肝炎
生物
癌症研究
乙型肝炎表面抗原
内科学
作者
Feiyang Zhao,Xiaoyu Xie,Xu Tan,Hongli Yu,Miaomiao Tian,Huanran Lv,Chengyong Qin,Jianni Qi,Qiang Zhu
标识
DOI:10.3389/fimmu.2021.691766
摘要
About 250 million people worldwide are chronically infected with Hepatitis B virus (HBV), contributing to a large burden on public health. Despite the existence of vaccines and antiviral drugs to prevent infection and suppress viral replication respectively, chronic hepatitis B (CHB) cure remains a remote treatment goal. The viral persistence caused by HBV is account for the chronic infection which increases the risk for developing liver cirrhosis and hepatocellular carcinoma (HCC). HBV virion utilizes various strategies to escape surveillance of host immune system therefore enhancing its replication, while the precise mechanisms involved remain elusive. Accumulating evidence suggests that the proteins encoded by HBV (hepatitis B surface antigen, hepatitis B core antigen, hepatitis B envelope antigen, HBx and polymerase) play an important role in viral persistence and liver pathogenesis. This review summarizes the major findings in functions of HBV encoding proteins, illustrating how these proteins affect hepatocytes and the immune system, which may open new venues for CHB therapies.
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