三氟甲基
表面改性
化学
组合化学
氟
有机化学
烷基
物理化学
作者
Tesfaye Tebeka Simur,Tian Yao,You‐Jie Yu,Feng‐Lian Zhang,Yifeng Wang
标识
DOI:10.1016/j.cclet.2021.08.043
摘要
Selective functionalization of C–F bonds in trifluoromethyl groups has recently received a growing interest, as it offers atom- and step-economic pathways to access highly valuable mono- and difluoroalkyl-substituted organic molecules using simple and inexpensive trifluoromethyl sources as the starting materials. In this regard, impressive progress has been made on the defluorinative functionalization reactions that proceed via radical intermediates. Nevertheless, it is still a great challenge to precisely control the defluorination process, due to the continuous decrease of the C–F bond strength after the replacement of one or two fluorine atoms with various functionalities. This review article is aimed to provide a brief overview of recently reported methods used to functionalize C–F bonds of CF 3 groups via radical intermediates. An emphasis is placed on the discussion of mechanistic aspects and synthetic applications Functionalization of C−F bonds of trifluoromethyl groups that proceed via mono- or difluoroalkyl radical intermediates has been summarized in this review .
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