In this work, the SnO2-CuO composite nanoparticles are fabricated as an ethanol gas sensor by one-step hydrothermal method, which is a core-shell structure composed of tetragonal tin oxide and monoclinic copper oxide. As ethanol gas sensor, the SnO2-CuO composite nanoparticles show excellent gas sensitivity and good selectivity to ethanol when deionized water as the hydrothermal solvent and Sn: Cu = 1: 1, and it have a small response recovery time of approximately 4 and 10 s respectively, and response value has a good linear relationship with the ethanol concentration between 50 and 300 ppm. The outstanding gas sensor character of the SnO2-CuO composite nanoparticles would be mainly attributed to special heterostructure and synergistic effect between tin oxide and copper oxide.