废止
化学
腈
激进的
药物化学
氢化物
双键
立体化学
劈理(地质)
分子内力
键裂
组合化学
有机化学
催化作用
金属
断裂(地质)
工程类
岩土工程
作者
Wen-Jin Xia,Tai-Gang Fan,Zhi-Wei Zhao,Xin Chen,Xiang-Xiang Wang,Ya-Min Li
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-07-27
卷期号:23 (15): 6158-6163
被引量:4
标识
DOI:10.1021/acs.orglett.1c02281
摘要
A novel annulation of 2-cyanoaryl acrylamides via C═C double bond cleavage has been developed for facile and efficient access to a broad spectrum of functionalized 4-amino-2-quinolones, which are important N-heterocycles. In this transformation, the solvent THF is demonstrated to play a crucial role, and the addition of alkyl radicals to nitrile, 1,5-hydride shift, and cleavage of the C-C bond are involved in the mechanism.
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