医学
幽门螺杆菌
幽门螺杆菌感染
免疫学
抗生素
螺杆菌感染
免疫系统
抗生素耐药性
养生
逃避(道德)
发病机制
消化性
消化性溃疡
重症监护医学
内科学
微生物学
生物
作者
Jae Hoon Cho,Akriti Prashar,Nicola L. Jones,Steven F. Moss
标识
DOI:10.1016/j.gtc.2021.02.001
摘要
Helicobacter pylori infection remains one of the most prevalent infections worldwide, causing significant morbidity and mortality from gastric malignancies and peptic ulcers. This article provides a summary of the microbiology and pathogenesis of this bacterium, emphasizing the complex and protean effects of H pylori on gastric epithelial cells, including stem and progenitor populations, and evasion of host immune defenses. Increasing antibiotic resistance has made management more challenging. This article discusses the appropriate diagnostic modality for different clinical scenarios, and the evolving treatment of H pylori infections, including the use of antibiotic susceptibility testing to aid regimen selection.
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