自愈水凝胶
静电纺丝
伤口愈合
明胶
材料科学
伤口敷料
透明质酸
体内
甲基丙烯酸酯
细胞外基质
皮肤修复
生物医学工程
高分子化学
化学工程
聚合物
复合材料
化学
聚合
外科
有机化学
生物化学
解剖
医学
工程类
生物技术
生物
作者
Keyan Zhang,Haijun Lv,Yuqi Zheng,Yueming Yao,Xiaoran Li,Jianyong Yu,Bin Ding
标识
DOI:10.1016/j.coco.2021.100752
摘要
Wound environment-responsive materials show great potential in skin repair. Herein, a temperature-responsive fibrous hydrogel was developed with the aid of the phase-change material of natural fatty acids. The extracellular matrix-like methacrylate gelatin (GelMA) nanofibrous hydrogels were fabricated via electrospinning and UV-crosslinking, followed by a depot of fatty acids/aspirin (ASP) encapsulated polydopamine (PDA). The as-prepared fibrous hydrogels showed a significantly faster ASP release at 40 °C compared with those of 25 °C and 37 °C, and an “on-off” drug release was achieved at heating and cooling cycles between 40 °C and 25 °C. The in vitro cell culture tests and in vivo wound healing study proved that GelMA-PDA-ASP nanofibrous hydrogels facilitated the cell growth and accelerated wound repair. Taken together, the thermosensitive drug-releasing nanofibrous hydrogel, showed a great potential for wound care.
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