膜性肾病
肾病综合征
泌尿系统
糖尿病肾病
尿
视黄醇结合蛋白
肾活检
内科学
生物标志物
医学
微小变化病
泌尿科
内分泌学
肾小球肾炎
胃肠病学
化学
活检
肾
生物化学
局灶节段性肾小球硬化
视黄醇
维生素
作者
Akira Araumi,Tsukasa Osaki,Kazunobu Ichikawa,Kosuke Kudo,Natsuko Suzuki,Sayumi Watanabe,Masafumi Watanabe,Tsuneo Konta
标识
DOI:10.1016/j.bbrep.2021.101102
摘要
The choice of treatment for primary nephrotic syndrome depends on the pathologic type of the disorder. Renal biopsy is necessary for a definitive diagnosis, but it is burdensome for the patients, and can be avoided if tests could be performed using urine or plasma. In this study, we analyzed 100 urinary proteins, 141 plasma proteins, and 57 urine/plasma ratios in cases of diabetic nephropathy (DN; n = 11), minimal change nephrotic syndrome (MCNS; n = 14), and membranous nephropathy (MN; n = 23). We found that the combination of urinary retinol-binding protein 4 and SH3 domain-binding glutamic acid-rich-like protein 3 could distinguish between MCNS and DN, with an area under the curve (AUC) of 0.9740. On the other hand, a selectivity index (SI) based on serotransferrin and immunoglobulin G, which is often used in clinical practice, distinguished them with an AUC of 0.9091. Similarly, the combination of urinary afamin and complement C3 urine/plasma ratio could distinguish between MN and DN with an AUC of 0.9842, while SI distinguished them with an AUC of 0.8538. Evidently, the candidates identified in this study were superior to the SI method. Thus, the aim was to test these biomarkers for accurate diagnosis and to greatly reduce the burden on patients.
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