肿瘤微环境
癌症研究
医学
临床试验
癌症
抗血管生成治疗
生物
计算生物学
生物信息学
内科学
作者
Leire Bejarano,Marta Joana Costa Jordão,Johanna A. Joyce
出处
期刊:Cancer Discovery
[American Association for Cancer Research]
日期:2021-04-01
卷期号:11 (4): 933-959
被引量:900
标识
DOI:10.1158/2159-8290.cd-20-1808
摘要
Abstract Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical roles of the TME in regulating tumor progression and modulating response to standard-of-care therapies. Here, we summarize the current knowledge regarding the most advanced TME-directed therapies, which have either been clinically approved or are currently being evaluated in trials, including immunotherapies, antiangiogenic drugs, and treatments directed against cancer-associated fibroblasts and the extracellular matrix. We also discuss some of the challenges associated with TME therapies, and future perspectives in this evolving field. Significance: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.
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