生物
祖细胞
转录组
细胞生物学
上皮
祖细胞
细胞分化
转录因子
表观遗传学
子宫
谱系(遗传)
干细胞
基因
基因表达
遗传学
作者
Bingbing Wu,Chengrui An,Li Yu,Zi Yin,Lin Gong,Zhenli Li,Yixiao Liu,Boon Chin Heng,Dandan Zhang,Zi Yin,Xiaohui Zou
标识
DOI:10.1016/j.stemcr.2017.05.022
摘要
The endometrial layer comprises luminal and glandular epithelia that both develop from the same simple layer of fetal uterine epithelium. Mechanisms of uterine epithelial progenitor self-renewal and differentiation are unclear. This study aims to systematically analyze the molecular and cellular mechanisms of uterine epithelial development by single-cell analysis. An integrated set of single-cell transcriptomic data of uterine epithelial progenitors and their differentiated progenies is provided. Additionally the unique molecular signatures of these cells, characterized by sequential upregulation of specific epigenetic and metabolic activities, and activation of unique signaling pathways and transcription factors, were also investigated. Finally a unique subpopulation of early progenitor, as well as differentiated luminal and glandular lineages, were identified. A complex cellular hierarchy of uterine epithelial development was thus delineated. Our study therefore systematically decoded molecular markers and a cellular program of uterine epithelial development that sheds light on uterine developmental biology.
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