信号灯
免疫系统
丛蛋白
受体
细胞生物学
化学
免疫学
淋巴细胞
生物
分子生物学
生物化学
作者
Е. М. Куклина,И. В. Некрасова
出处
期刊:Doklady Biological Sciences
[Springer Nature]
日期:2017-03-01
卷期号:473 (1): 84-88
被引量:3
标识
DOI:10.1134/s0012496617020028
摘要
Novel targets for action of the class IV semaphorin Seam4D have been identified in the immune system. The low-affinity CD72 receptor for Seam4D was detected not only on B lymphocytes, but also in a proportion of T cells, whereas the high-affinity semaphorin receptor, plexin B1, originally considered to belong to non-immune cells, proved to be in a great proportion of intact T and B cells. Seam4D is constitutively expressed in B cells, which, along with T cells, can serve as a source of both membrane and soluble semaphorin. The results obtained make significant adjustments in understanding of Seam4D effects in lymphoid cells.
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