细胞生物学
自噬
效应器
内质网
炎症体
生物
嗜肺军团菌
线粒体
分泌物
致病菌
吞噬体
细胞器
内膜系统
细菌
高尔基体
微生物学
细胞内
生物化学
细胞凋亡
炎症
免疫学
遗传学
作者
Pedro Escoll,Monica Rolando,Carmen Buchrieser
出处
期刊:BioEssays
[Wiley]
日期:2016-12-27
卷期号:39 (2)
被引量:15
标识
DOI:10.1002/bies.201600171
摘要
Pathogenic bacteria frequently target the endoplasmic reticulum (ER) and mitochondria in order to exploit host functions. ER‐mitochondria inter‐organelle communication is topologically sub‐compartmentalized at mitochondria‐associated ER membranes (MAMs). MAMs are specific membranous microdomains with unique regulatory functions such as lipid synthesis and trafficking, calcium homeostasis, mitochondrial morphology, inflammasome activation, autophagosome formation, and apoptosis. These important cellular processes are all modulated by pathogens to subvert host functions and promote infection, thus it is tempting to assume that pathogenic bacteria target MAMs to subvert these different pathways in their hosts. First lines of evidence that support this hypothesis come from Legionella pneumophila . This intracellular bacterium secretes an effector that exhibits sphingosine‐1 phosphate lyase activity ( Lp Spl) that seems to target MAMs to modulate the autophagy response to infection. Here we thus propose the concept that MAMs could be targeted by pathogenic bacteria to undermine key host cellular processes.
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