转鼓
卡宾
催化作用
化学
区域选择性
有机催化
反应性(心理学)
组合化学
立体选择性
路易斯酸
对映选择合成
有机化学
医学
病理
亲核细胞
替代医学
作者
Michael H. Wang,Karl A. Scheidt
标识
DOI:10.1002/anie.201605319
摘要
Abstract N‐Heterocyclic carbene (NHC) catalysis has emerged as a powerful stratagem in organic synthesis to construct complex molecules primarily by polarity reversal (umpolung) approaches. These unique Lewis bases have been used to generate acyl anions, enolates, and homoenolates in catalytic fashion. Recently, a new strategy has emerged that dramatically expands the synthetic utility of carbene catalysis by leveraging additional activation modes: cooperative catalysis. The careful selection and balance of cocatalysts have led to enhanced reactivity, increased yields, and improved stereoselectivity. In certain cases, these catalytic additives have changed the regioselectivity or diastereoselectivity. This Minireview highlights new advances in NHC cooperative catalysis and surveys the evolution of this field.
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