1,3‐Enynes have demonstrated their utility as valuable precursors to furnish a diverse range of heterocycles and carbocycles. Their unique structural characteristics enable a new toolbox to introduce requisite complexity in the molecular framework. Cyclization reaction is usually a simple and straightforward way to afford complex organic frameworks. Herein, we collated versatile cyclization strategies that have been developed by employing 1,3‐enynes for the synthesis of heterocyclic and carbocyclic scaffolds. Divergent synthesis and mechanistic perspectives to define stereo‐, regio‐ and chemo‐selective outcomes of such reactions have also been highlighted.